This species is known from its type locality within the Brazilian Amazon forest. It was collected in 2007 and never found again. Cantharellus amazonensis was found growing gregariously among soil and litter in a forest managed in an agroecological village near Manaus, Amazonas state's capital. Despite the lack of data to infer its potential occurrence range, it is plausible to suspect that the species occurs along the Amazon where its specific (and up to now unclear) biotic and abiotic requirements are met. The species produces large and conspicuous basidiomes with red pileus and yellow stipe, contrasting with soil and litter where it is found growing. The species probably forms symbiotic relationships with an unknown plant host, as species within Cantharellus are considered to be ectomycorrhizal. The species' rarity, despite its conspicuous basidiomes, and lack of distribution data leads to minimal understanding of its potential distribution, ecology, and niche requirements. More efforts are required to understand the species' needs, past and current trends, and if it is facing significant threats. Therefore, C. amazonensis is assessed as Data Deficient.

Cantharellus amazonensis is known only from its type locality, within the Brazilian Amazon forest, in an agroecological village near Manaus, Amazonas state's capital. The species' rarity, considering its conspicuous basidiomes and single collection, hinders understanding and leads to an inability to accurately estimate extent of occurrence or area of occupancy. Nevertheless, it is possible that the species occurs within the Amazon region in similar habitats, possibly associated with a specific host, as Cantharellus species are considered ectomycorrhizal.

The species is currently only known from its holotype, within an agroecological village near Amazonas state capital, Manaus. Cantharellus amazonensis produces large and conspicuous basidiomes with a red pileus and yellow stipe, contrasting with soil and litter where it is found growing. It is suspected to form a symbiotic relationship with an unknown plant host. Despite its sporomes' conspicuousness and considerable sampling efforts within the Manaus region, the species has never been found again since its description in 2012, rendering it potentially a highly rare species. Considering this, with currently available data, it is not possible to estimate population parameters or understand the species' niche requirements to infer its potential area of occurrence. Nonetheless, the species' current known occurrence area and habitat suffer pressures insofar as the natural areas near Manaus and in the Brazilian Amazon, in general, are affected mainly by deforestation, which has worsened in recent years, together with urban expansion and lack of enforcement of laws and policies. These are all potential threats to C. amazonensis and to the stability of its unknown population, as habitat quality is directly tied to species occupation (Berglund and Jonnson 2003, Haddad et al. 2015).

Cantharellus amazonensis grows gregariously among soil and litter in the Brazilian Amazon, on terra firme soils, within an agroecological village near Manaus, Amazonas state's capital. Despite the lack of data to infer its potential occurrence range, it is plausible to suspect that the species occurs along the Amazon where its specific biotic and abiotic requirements are met. The species produces large and conspicuous basidiomes with red pileus and yellow stipe, contrasting with soil and litter where it is found growing. The species probably forms symbiotic relationships with an unknown plant host, as species within Cantharellus are often ectomycorrhizal.

The species is potentially be threatened by deforestation, assuming that it cannot thrive under habitat disturbance. Around 18% of the Brazilian Amazon forest has been cleared, with average annual losses in the last decade of 1.8 million hectares per year (INPE 2020). The development of infrastructure is also recognized as a contributing driver of this forest loss. Lack of enforcement of laws and policies for effective management of the Amazon is also contributing to the loss and degradation of habitat.

No use/trade is known, but Cantharellus species are generally edible and consumed locally.

Direct and precise conservation actions aiming to preserve Cantharellus amazonensis are currently hindered by lack of knowledge regarding the species' distribution, population size and trends, and potential niche. However, a cautionary solution would include protection of its type locality and adjacent areas, where there is a bigger probability of C. amazonensis' occurrence. As the Brazilian Amazon suffers high deforestation rates (INPE 2020) and there is a lack of legislation enforcement, these measures could protect the unknown subpopulations as a whole. Further research and sampling efforts are needed in order to better understand the species' distribution and potential niche, which would in turn enable total population inferences and threat mapping. Additionally, Cantharellus species are generally symbionts, thus ecological research regarding the species' potential hosts would increase its ecological and niche understanding.