Dimorphanthera nigropunctata is known from two montane areas within Indonesian New Guinea, the Mount Nettoti area and the southern side of Mount Jaya. There is one tentative record from Mount Wilhelm in Papua New Guinea, which is excluded here due to its uncertain identification and morphological differences. No numerical population information is available for this species. The area of occupancy (AOO) of 16 km² and the extent of occurrence (EOO) of 4,228 km² fall within the threshold values for the Endangered category under Criterion B. Near Tembagapura, road building is leading to increasing human presence and ecosystem disturbance in the region, plus mining-related activities such as the disposal of tailings. On Mount Nettoti, the forest is mainly intact apart from scattered landslides and the population at this location is unlikely to be threatened. Increasing fire frequency due to increasing droughts caused by climate change is a possible future threat in both these montane areas. There are large areas of intact habitat forest available for this species at both its recorded sites, however, an ongoing and future loss of habitat area, extent and quality due to the reported threats can be inferred in the Mount Jaya region. The lack of collections of this species mean that it may be widespread, and the large areas of potential montane habitat mean that it may be Least Concern. Based on available data, however, the known EOO and AOO meet the threshold for Endangered and there is a continuing decline in the extent and quality of its habitat. It is however expected that the majority of the known population occurs in the Mt. Nettoli area, where threats are sufficiently localised that locations have not been defined. Therefore this species is assessed as Near Threatened, on the basis that it meets Criteria B1b(iii)+B2b(iii) but is not presently considered to occur at 10 or fewer locations or as a severely fragmented population, and is not expected to undergo extreme fluctuations.

Dimorphanthera nigropunctata is known from several sites across Indonesian New Guinea, primarily through the Mount Nettoti Range and the Tembagapura area on the south side of Mount Jaya. There is a potential record from Mount Wilhelm in Papua New Guinea, which is excluded here as its identity has been only tentatively determined and has larger leaves and a denser inflorescence than the type (van Royen and Sleumer #8110). It has been recorded between 1,550 and 2,000 m asl.

No population information is available for this species, and the current population trend is unknown.

This species is recorded as occurring in mossy Nothofagus forest, riverine forest, and secondary shrubbery on cliffs (Sleumer 1963). As with the rest of the genus it is a mid- to high-elevation species. The plant is described on herbarium specimen labels as a climber or epiphytic shrub between 2 and 4 metres tall.

The largest threat to biodiversity in the Mount Jaya area is the Grasberg gold and copper mine. The open cast pit is located above 3,800 m asl, above the zone where this species occurs (the maximum recorded elevation is 2,000 m asl). However, the mine activities extend beyond the pit itself, including the dumping of mine overburden and increased human disturbance, particularly along the mine roads (Utteridge and Edwards 2009). IUCN (2020) lists the greatest threats to Lorentz National Park as road construction and ineffective management which is unable to deal with emerging threats. On Mount Nettoti, satellite images show few disturbances to the forest apart from scattered landslides (Global Forest Watch 2023).

All the alpine areas of New Guinea, including the two areas where this species has been recorded, are threatened by climate change causing increasingly severe droughts which lead to increased frequency of fire (Hope 2014, Supari et al. 2016). This is likely to result in a decrease in the area of the non fire-adapted mossy forests which favour epiphytes like Dimorphanthera.

This species is not known to be used.

The summit region of Mount Jaya is in the Lorentz National Park, a UNESCO World Heritage Site covering 23,500 km². The conservation outlook for this site was listed as "Significant Concern" by IUCN in 2020, due primarily to ineffective management and monitoring. The known sites for Dimorphanthera nigropunctata are close to Tembagapura, which is outside this protected area. Mount Nettoti, the other known site for this species, is inside the Tamrau Utara, a 3,684 km² national-level nature reserve managed by Balai Besar Konservasi Sumber Daya Alam Papua Barat. The species is not found in any ex situ collections (BGCI 2022).