This is a range-restricted species, endemic to Greece. It is known from the mountains of Sterea Ellas, making it rare in the country. Its extent of occurrence (EOO) is around 1,867 km², its area of occupancy (AOO) is 48 km², and it occurs in 8–10 locations. In the past it was believed to be an endemic only on Evvia, but it was recently rediscovered in Parnitha. Research and monitoring of the species are extremely urgent, as the establishment of wind turbines on the mountain summits the species grows, will probably result in the destruction of the species in these sites. Another threat the species possibly faces, could be climate change, which also leads to higher frequency in fire bursts. The quality of habitat is already under decline due to to the aforementioned threats. The species is classified as Vulnerable under B1ab(iii,v)+2ab(iii,v).

Hypericum fragile is a range-restricted endemic of Greece. It grows on the island of Evvia and on Mount Parnitha (Dimopoulos et al. 2022, Polymenakos et al. 2022, Strid 2022).

The species is known from sparse subspopulations, in central and north Evvia and on Parnitha mountain. In Evvia it is found in Ano Steni, south of the village Metochi, in Chiliadou beach, in the gorge near Manikia village, in the Agali gorge and on the east slopes of Mount Kandili (Trigas 2009). According to the same author, the largest subpopulation in Evvia appears to be the one in the gorge close to Manikia village, consisting of several hundreds individuals. The Chiliadou subpopulation measured 200 individuals approximately. The rest subpopulations consist of a few dozens each, the smallest one being near Metochi village (seven individuals). It was estimated at the time that the total number of individuals in Evvia was fewer than 2,000. In Parnitha, it was found on the north side of the mountain (Polymenakos et al. 2022), collected by Polymenakos and Pantavos, confirming Pinatzi's collection of 1936. A fine population was found on west-facing cliffs, together with Inula verbascifolia, Centaurea attica and Bufonia stricta. The true size of the total population is unknown.

Hypericum fragile grows on vertical limestone rocks, usually of north exposure, offering more or less shade and humidity during winter (Trigas 2009). The plants do not develop inside rock fissures. Instead, they penetrate the limestone substrate with their roots. This process seems to be facilitated by the damp conditions of the species' habitat. Following the death of a plant, a hole is seen in the rock, with equal diameter to the powerful plant's root diameter. Often, due to this harsh environment, the subpopulations of H. fragile are unaccompanied by other taxa. Wherever the species coexisted with other taxa, they were typical chasmophytes, such as: Athamanta macedonica, Aubrieta scyria, Amelanchier parviflora subsp. chelmea, Silene multicaulis subsp. sporadum, Scrophularia heterophylla, Teucrium flavum subsp. hellenicum, Stachys tetragona, Brassica cretica subsp. aegaea, Asperula euboea etc.

The species grows in particularly hard to reach sites, so effectively it is protected from grazing. However, fires which are increasingly frequent and devastating, are threatening its habitat. Also, its biggest subpopulation is in imminent danger, due to windfarms, which will be established in that area, according to the Greek Regulation Authority for Energy (2023). It is doubtful if the species will survive in these localities. The construction of roads in steep slopes and the flattening of the mountain ranges, in order for the wind turbines to be established, will be catastrophic. Also, the species is going to be drastically affected by climate change and a possible future decline in precipitation (Trigas 2009). As it is a lithophyte, penetrating rocks, it depends heavily on rain. The Hellenic Ministry of Environment and Energy has created climate change projection maps (2023), in the frame of a LIFE programme, with the contribution of the Athens National Observatory and the Athens Academy of Sciences. According to the map of change in number of precipitation days per year in the near future (2031–2060), in relation to years 1971–2000, based on the average of seven chosen simulations of EURO-CORDEX (HadGEM2-ES_r1i1p1_RCA4, MPI-ESM-LR_r1i1pi_RCA4, EC-EARTH_r3i1p1_ΗΙRΗΑΜ5, EC-EARTH_r12i1p1_CCLM4-8-17, CNRM-CM5_r1i1p1_RACMO22E, HadGEM2-ES_r1i1pi_RACMO22E and MPI-ESM-LR__r1i1pi_REMO2009), according to emissions scenario RCP8.5, the habitat of Hypericum fragile will face a decrease of rainy days per year, by 8 to 14 days. Therefore, it is believed that it will be affected by climate change in the following years, with loss of mature plants.

The species is found in nurseries worldwide and is traded for gardening. The genus Hypericum is known to be used for pharmaceutical purposes.

Some locations, where Hypericum fragile is found, are within Natura 2000 sites, namely: GR3000001 (OROS PARNITHA), GR2420011 (ORI KENTRIKIS EVVOIAS, PARAKTIA ZONI KAI NISIDES) and GR2420010 (OROS KANTILI). The species is also protected by law (Presidential Decree 67/1981), but no conservation measures have been taken so far. Research has to be done for the entire population of the species, in order to effectively protect it, as well as for its ecology, the threats it faces in every site and actions that must be taken towards its conservation. Monitoring its subpopulations for several years, along with planning its recovery and management of the area it occupies, are extremely urgent. Germplasm must be kept in seed banks. The taxon is found in six Botanical Gardens (BCGI 2023). Citizens' awareness and communication of the significance of this taxon for the country's environment will also play a huge role for its survival. The state has to enforce its law. Further research and monitoring of this species is needed.