Erythrina senegalensis has a wide distribution range, occurring across all west tropical Africa: Benin, Cameroon, Chad, Gambia, Ghana, Guinea, Guinea Bissau, Côte d'Ivoire, Liberia, Mali, Niger, Nigeria, Senegal, Sierra Leone and Togo. The species is used in traditional medicine to cure several diseases and for its antibacterial properties, but at present that does not seem to affect the population dynamics of the species. There are no other major known threats for the species and the population is currently believed to be stable, therefore the species is rated as Least Concern.

Erythrina senegalensis is distributed in Africa: Benin, Cameroon, Chad, Gambia, Ghana, Guinea, Guinea Bissau, Côte d'Ivoire, Liberia, Mali, Niger, Nigeria, Senegal, Sierra Leone, Togo.

E. senegalensis is generally described as common in Sierra Leone.

E. senegalensis is a tree which occurs in dry open savanna woodlands, burned savanna, plateau with fine gravel, degraded regrowths, coastal savanna (in Ghana), bank of streams and roadsides by grassland.

The species is also often cultivated as ornamental tree and as hedge plant.

There are no known threats to the species at present.

Erythrina senegalensis is used in traditional medicine to cure several diseases: amenorrhoea, malaria, jaundice, infections, abortion, wound, and body pain (chest pain, back pain, abdominal pain etc).
The species is also often cultivated as ornamental tree and as hedge plant.

There are no known conservation measures specifically for E. senegalensis, however, the species is known to occur in many protected areas.
Seed of E. senegalensis should be collected and stored in the Millennium Seed Bank as an ex situ conservation measure.