Guatteria flexilis is well recognizable by its scabridulous almost completely glabrous leaves combined with relatively long pedicels of up to c. 50 mm long in fruit (Maas et al. 2015).

This species, native to Venezuela and Guyana, is known from fewer than five occurrences. There is also no information on population size and trends. There are general threats of habitat loss. However, because of this lack of data no trustworthy assessment could be made, this species was considered Data Deficient.

This species is recorded from Amazonian Venezuela (Bolívar, Delta Amacuro), and Guyana.

The current population size and population trend of this species are unknown.

This species grows in non-inundated, primary or secondary forest, the type collection from Greenheart (Chlorocardium rodiaei) forest, on sandy or lateritic soil at elevations of 0–120 m. It is flowering in March to May, August, and September, and fruiting in February, March, May, and September (Maas et al. 2015).

Habitat loss because of forest cover loss is a possible threat for all species of Guatteria (Da Silva et al. 2005, Malhi et al. 2008, Hansen et al. 2013).

No specific conservation actions are currently undertaken.