Proagoderus quadrituber has been assessed as Least Concern as it occurs across a very wide area and its presence in reserves is sufficient to prevent any risk of extinction. However, it seems to have a fairly localised area of occurrence, apparently due to soil type specialisation on clay in densely woody areas. Although it has been trapped with a variety of dung types these were mostly combined together in composite baits. Although it receives a measure of protection in uMkhuze Game Reserve in South Africa and in Kyle (now Lake Mutirikwe) Game Reserve in Zimbabwe, there is insufficient ecological and range information to determine if it is under any particular threat, for instance, from thinning or clearance of dense woodland on clay soils. Therefore, further research on range, soil, vegetation, and dung type associations is recommended to support future reassessments of this species.

This species was described from Chinde in the Pungwe River Valley in central Mozambique (d'Orbigny 1908), but is now represented by a lectotype from Guengère in the same valley. It occupies a patchy occurrence in the lower altitude, hot, moist, eastern savannas of southern Africa (Malawi, Mozambique, South Africa and Zimbabwe), partly as a result of its soil and vegetation specialisation, and possibly also partly as a result of collection bias (Australian CSIRO 1970-1986, unpublished records; Schoolmeesters 2011). Its extent of occurrence has been estimated at 134,250 km², and its area of occupancy is "probably a small fraction" of this, especially if as suspected it is associated with the presence of dense woody vegetation (Davis et al. 2020).

The only existing population data show that this species occurs in fair abundance in appropriate habitat.

Although there are collecting records from savanna woodland on both sand and clay in uMkhuze Game Reserve in South Africa (Australian CSIRO 1970-1986, unpublished records), quantitative trapping across a range of soil types recorded this species (total 30 individuals) almost exclusively on clay (2.3 per trap) near Nsumu Pan (Doube 1991), which may explain its apparent patchy occurrence in woodland near pans and in river valleys. It was absent from deep sand and sandy clay loam (makatini), but occurred as a rarity on duplex soils of sand overlying clay (0.3 per trap). It has been recorded on rhinoceros dung and trapped to mixtures of pig, cattle and horse dung as well as a human/cattle dung mixture (Australian CSIRO 1970-1986, unpublished records).

This species occurs on patches of wooded clay soils in an eastern savanna block comprising the Southern Miombo woodlands (AT0719), Zambezian and Mopane woodlands (AT0725), Maputaland coastal forest mosaic (AT0199) and Zambezian coastal flooded savanna (AT0906), with two coastal localities even coinciding with the edge of East African Mangoves (AT1402) (ecoregions based on Olson et al. 2001). Davis et al. (2020) suggest that it may exhibit an association with dense woody vegetation, although records they summarise include two from grassland.

Some environmental characteristics for twenty locality records are as follows: mean elevation: 362 ± 428 (S.D.), range: 0-965 m; annual rainfall: mean: 854 ± 211 (S.D.), range: 670-1,337 mm; annual temperature: mean: 21.9 ± 2.0 (S.D.), range: 19.8-25.5 °C. Data from southern Africa indicates records as high as 1,377 m, and temperatures as low as 17.3 °C (Davis et al. 2020).

Although this species occupies a wide distribution, it seems that it shows quite localised occurrence due to its soil type specialization. There is insufficient ecological and range information to determine if it is under any particular threat, such as clearance of dense woody vegetation. Within South Africa there has been a moderate rate of forest clearance, with 22-25% of native vegetation having been lost from vegetation units within its range, but much of the remainder is within reserves (Davis et al. 2020).

There is no use or trade information available for this species.

There are no species-specific conservation actions in place for this species, although it occurs in a number of reserves including Lake Mutirikwe (Zimbabwe) and uMkhuze, Hluhluwe–iMfolozi (South Africa). In order to provide an accurate assessment of the extinction risk of this species, it is necessary to survey patches of riverine or lacustrine clay in southeast Africa using various baits. It is also unclear if it is associated with dense woody vegetation or open locations, as it was trapped equally in grassland (43%) and shade in uMkhuze Game Reserve, South Africa. Better data are needed to support a hypothesised preference for wooded habitats.