Globularia stygia has a restricted distribution (area of occupancy of 20-28 km²) and is rather specialised to its habitat, but it grows mostly at inaccessible places and apparently faces no immediate threats. The current population trend is unknown. It can potentially be threatened by collection.

This plant is endemic to the Peloponnisos in southern Greece. It is found at Chelmos Mt, Kyllini Mt and Taygetos Mt. The extent of occurrence is around 1,200 km² and the area of occcupancy is 20-28 km².

There are four to five subpopulations in six to eight locations. The population size has not been counted or systematically monitored but it is locally quite abundant (a cover of often 5-25%) in chasmophytic or Oro-Mediterranean low spiny shrub communities.

Globularia stygia grows in ravines, rock crevices, cliff ledges, open scree slopes, sometimes in semi-shade in mixed Abies cephalonica-Pinus nigra forest, on limestone or schist at altitudes from 1,150-2,300 m. (Commission of the European Communities 2009). It forms part of the plant community Astero alpini-Globularietum stygiae.

The species is not under any immediate threat of extinction, but as it is collected by botanists and shows horticultural potential, it may be in greater demand in the future (Commission of the European Communities 2009).

Collection for the horticultural trade has been mentioned as a potential threat.

Globularia stygia is listed as priority species on Annex II of the Habitats Directive and under Appendix I of the Convention on the Conservation of European Wildlife and Natural Habitats (Bern Convention). It is protected in Greece by the Presidential Decree 67/81 and included in the Red Data Book (1995). All of the population of the plant is included in the Natura 2000 sites GR2320002, GR2530001, and GR2550006.