In certain part of the distributional range of Pila globosa, it is a preferred food source by human and it is also used as food in poultry industry; however, this is not a threat to the species. Due to its near pan global distribution it is assessed as Least Concern.

Pila globosa recorded from Nepal, southwestern Asia, Africa, north and south America (Subba Rao 1989). It is a common species in India except southern India and Punjab; it is found in Assam, Bihar, Maharashtra, Madhya Pradesh, Meghalaya (South Garo Hills), Orissa, Uttar Pradesh and West Bengal.

There is no population level information about this species. Though the population is widespread, in certain regions like Nepal the population is decreasing due to habitat loss, agricultural intensification and fish poisoning.

This species lives in permanent and temporary stagnant water bodies and uses dry areas for breeding. Adults survive the dry season buried in soil. A number of trematodes like Artyfechinostomum sufratyfese, Echinostoma cercaria, Cercaria andhraensis, C. pigmentata, Diplodiscus sp., and Xiphidocercaria sp. are  reported from this species (Subba Rao 1989).

No information is available on specific threats apart from general threats that exists in most of the habitats of this species. The population of this species in Nepal is decreasing due to habitat loss, agricultural intensification and fish poisoning and over harvesting are some inferred threats to this species.

Pila globosa is commonly used as food by some people, mainly the tribals and lower economic groups in Nepal, the Sunderbans as well as the people of West Bengal, Bihar, Uttar Pradesh and other parts of India. It is one of the most preferred gastropod species utilised by tribal people as food. This species is also valuable source of nutrition for ducks and hybrid fish Magur (Clarias batrachus). In addition, soup prepared from the flesh is used as medicine that is believed to cure asthma, arthritis, joint swelling, rheumatism and in quick healing of wounds. The snail is cleaned and kept in water for a few hours and then the water is used like an eye drop to cure conjunctivitis (Subba Rao 1989).

Studies into the impact of harvesting on the population of the species is required.