Diospyros sprucei is known only from the type specimen collected in 1853 in San Carlos. As far as is known, this species does not occur inside a protected area. As the locality is uncertain, the degree of threat is also unknown. It is not possible to estimate the extent of occurrence (EOO), and the area of occupancy (AOO) is estimated at 4 km².

Given the lack of data and the fact that the species was described from material collected in 1853, it would be preferable if further studies, seeking to find the species in other localities and obtain population data in the region close to the type locality, would be undertaken. It is desirable to improve knowledge about its distribution and population dynamics and, thus, enable a robust assessment of its risk of extinction. It is not known from any formally protected areas.
In view of the lack of information and until additional collections or observations are made for Diospyros sprucei, the Red List assessment is Data Deficient.

Diospyros sprucei is known only from the type collection made by Richard Spruce in 1853 in San Carlos, southern Venezuela. It is not possible to estimate the extent of occurrence (EOO) and the area of occupancy (AOO) is estimated at 4 km².

The population status for Diospyros sprucei is unknown, as it is only known from the type collection made in 1853.

There is no habitat or ecology information published for Diospyros sprucei. The type collection is from lowland, moist tropical rainforest.

The threats are unknown for Diospyros sprucei as it is only known from the type collection (1853).

There is no published information on the use or trade for Diospyros sprucei.

As far as is known, Diospyros sprucei does not occur inside a protected area.