Bulimnaea megasoma has been assessed as Least Concern as it is widely distributed and abundant throughout North America with no current threats affecting the global population.

This species is widespread in northern America, ranging from Iowa north to Manitoba in Canada, east to Quebec and south to Pennsylvania, although it is now thought to be extirpated from Vermont and New York (NatureServe 2009). This species occurs in the Great Lakes and St. Lawrence River drainage area, upper tributaries of the Mississippi drainage area, and parts of the Albany, Winnipeg and Nelson River systems in the Canadian Interior Basin (Burch 1989, Clarke 1981, Hubendick 1951). Baker (1911) included northern New England (in Vermont) west to Minnesota, Iowa and Manitoba; northern Ohio at a latitude of 41 degrees, northward to a latitude of 57 degrees.

There is no population information available for this species.

This species is known from freshwater rivers (NatureServe 2009).

There are no major threats to this species, although it is likely to be locally threatened by habitat degradation and loss.

This species is not utilised.

This species has been given a Global Heritage Status Rank of G4 - Apparently Secure and G5 - Secure by NatureServe (2009). There are no species-specific conservation measures in place.