Calophyllum blancoi occurs in the Philippines, Malaysia and Singapore. It is occurring in primary and secondary forests, dipterocarp forest, mossy forest, riverine forests in the Philippines and Malaysia as well as in lowland mixed dipterocarp and evergreen forests of Singapore. It has a calculated extent of occurrence (EOO) of 2,984,796.137 km². Though the population size is currently not known, a continuous decline is expected due to habitat-threatening effects of commodity-driven deforestation, logging, shifting cultivation, and urbanization. However, despite these threats affecting the population and natural habitat quality, it is assessed globally as Least Concern (LC) given its numerous occurrences, very wide distribution, and expected abundance.

Calophyllum blancoi is native to the Philippines, Malaysia, and Singapore. In the Philippines, it is naturally found in primary and secondary forests, dipterocarp forest, mossy forest, riverine forests of Agusan del Norte, Albay, Aurora, Antipolo, Bataan, Batanes, Benguet, Bukidnon, Bulacan, Camarines Sur, Cavite, Davao del Sur, Ifugao, Ilocos Sur, Ilocos Norte, Isabela, Laguna, Lanao del Sur, Leyte, Mountain Province, Nueva Ecija, Palawan, Pampanga, Pangasinan, Quezon, Samar, Sorsogon, Surigao del Norte, South Cotabato, Tawi-Tawi, Zambales, and Zamboanga del Sur. It can also be found in Malaysia (Perak, Sabah, Sarawak, and Selangor) as well as in lowland mixed dipterocarp and evergreen forests of Singapore (North and Central). It usually grows at an elevation of 12 to 1,900 m above sea level (Pro-Seeds Development Association, Inc. 2019, GBIF.org 2021, CDFP 2021). It has an extent of occurrence (EOO) of 2,984,796.137 km² accounting for its 62 identified localities that are continuously threatened by commodity-driven deforestation, logging, shifting cultivation, and urbanization (GFW 2021).

In 2019, 106 individuals of Calophyllum blancoi were recorded by Pro-Seeds Development Association, Inc. -  one in Pampanga, three in San Roque, Pangasinan, six in Tampakan, South Cotabato, 14 in Ormoc, Leyte, 20 in UP Laguna Land Grant, eight in UP Land Grant Quezon, and 54 in Maragundon, Cavite. The total population size, however, remains uncertain due to lack of research initiatives– which can be addressed by further inventory and documentation. It is expected that there is continuous population decline due to continuing forest losses within the localities of the species induced by commodity-driven deforestation, logging, shifting cultivation, and urbanization.

The height of Calophyllum blancoi from herbarium records ranges from two to 35 metres. It occurs in primary and secondary forests, dipterocarp forest, mossy forest, riverine forests in the Philippines and Malaysia as well as in lowland mixed dipterocarp and evergreen forests of Singapore (GBIF 2021). The phenology of the species has not been well-documented but based on CDFP (2021), the species flowers from February to July, and rarely in January, August, September, November, December, and sets fruit throughout the year.

Calophyllum blancoi is primarily threatened by land conversion and habitat degradation caused by commodity-driven deforestation, logging, shifting cultivation, and urbanization. Based on analyzed data from the Global Forest Watch, a significant loss of humid primary forest from 2001 to 2020 is reported across the range of the species - 27,151.15ha in its localities in the Philippines.

The wood of Calophyllum blancoi is used for fuel, house construction, and wood carving. It is also a voucher specimen for anticancer and anti-AIDS screening (GBIF.org 2021).

The species is not included in the Philippine Red List (DENR-BMB 2017). Its occurrence in Protected Areas (PAs) in the Philippines (Batanes Protected Landscape & Seascape, Northern Sierra Madre Natural Park, Marcos Highway Watershed Forest Reserve, Lower Agno Watershed Forest Reserve, Olongapo Watershed Forest Reserve, Angat (Pilot) Watershed and Forest Range, Upper Marikina River Basin Protected Landscape, Mts. Palay-palay-Mataas-na-Gulod Protected Landscape, Bulusan Volcano Natural Park, Samar Island Natural Park, Cabadbaran Watershed, Mt. Kitanglad Range Natural Park, Lake Lanao Watershed Reservation, Mt. Apo Natural Park Buffer Zone, Malampaya Sound Protected Landscape, and Palawan Flora, Fauna and Watershed Forest Reserve (Parcel 1)) and Malaysia (Selangan Island, Pulau Banggi, and Bako National Park) serves as in situ conservation of the species. It is also found in Key Biodiversity Areas (KBAs) including Mount Dingalan, Manila Bay, Mariveles mountains, Mounts Irid-Angilo and Binuang, University of the Philippines Land Grants (Pakil and Real), Mounts Palay-Palay-Mataas Na Gulod National Park, Anonang-Lobi Range, Mount Hilong-hilong, Mount Apo Natural Park, Mount Matutum Protected Landscape, Malampaya Sound Protected Landscape and Seascape, and Victoria and Anepahan Ranges. In addition, it is known in at least four botanic garden globally (BGCI 2021). Further inventory and research are needed to account for total remaining population size in the wild.